Citrulline is an α- Amino acid named “citrulline” because it was first obtained from watermelon.

When citrulline is still an amino acid, because it is not encoded for DNA, it will not be embedded in proteins in protein biosynthesis, but some proteins still contain citrulline. These citrullines are produced by peptide arginine iminase (PAD), which converts arginine to citrulline in the process of melon ammoniation. Generally, citrulline proteins include human brain myelin essential protein (MBP), polykeratin microfilament, and histones. For example, cellulose and vimentin can be ammoniated from cell death and tissue inflammation.

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