In many public opinions, you will see two completely different statements. Some people say that their skin has improved after taking collagen, and there are articles criticizing collagen.
So, how to find the truth in complicated and contradictory information? Very simple, the most scientific way is: look at the literature! It is always right to speak with data.
The following is the latest research progress of collagen summarized from the massive literature. I hope to help everyone see the legend of collagen with a rational perspective:
In 2014, Proksch E et al. randomly divided 114 women aged 45-65 into two groups for double-blind experiments. Each group received 2.5g of collagen peptide or placebo once a day for eight weeks. After eight weeks, the collagen peptide group ingested the eye wrinkles are significantly lower than the placebo group (p <0.05), and this effect can continue four weeks after the drug is stopped (only the four weeks time point was measured) Keep (p <0.05)
In 2015, Asserin J. et al. found in a double-blind experiment that the experimental group of oral collagen hydrolysates observed an increase in collagen density and a decrease in the degree of damage to the collagen network from the 4th week, and the collagen at the 8th week The skin hydration of the group increased significantly. These effects can continue to be maintained 4 weeks after stopping the drug.
In 2016, Inoue N. et al. found in a randomized double-blind clinical study that intake of bioactive collagen hydrolysate can improve facial skin conditions, including facial skin moisture, elasticity, wrinkles and roughness, and reduce facial aging signs. In addition, They also evaluated the safety of these peptides as dietary supplements through blood tests.
Experiments have proved that taking collagen hydrolysate (also called collagen peptide) can improve skin elasticity, increase water content and reduce wrinkles.
When asked why, what are the principles?
Principle 1: Small collagen peptides (oligopeptides) can be directly absorbed by the intestine and sent to the skin
Principle 2: The role of oligopeptides in the dermis
With the development of science and technology and the growing demand for green and safe food, the functions of collagen peptides are gradually being revealed, and they are also widely used in the human market. Therefore, the future research directions of collagen peptides may focus on the following aspects:
①: Starting from the perspective of prevention and clinical medicine, develop more characteristic drugs or encapsulated bioengineering materials suitable for human diseases that can replace human tissues and organs; chitosan heat-sensitive collagen peptide nanoparticles are used in drug delivery, and tissue Repairing and thermally hydrolyzed collagen gels are gradually being used clinically in cell encapsulation and wound healing.
②: Considering genetic engineering, protein engineering, and genomics, manufacturing recombinant collagen, using collagen/peptide fingerprints to trace the origin of organisms. The latest report in this area is collagen peptide maps to study the source of Japanese archaeological chickens and pheasants.
③: Starting from human metabolomics and physiology, develop human-like collagen peptides, nano-particle collagen peptides, and drug-gene delivery systems.
④：From the perspective of the human diet and nutrient absorption, more collagen peptide dietary supplements will be developed, such as non-toxic and harmless peptide calcium chelate to promote the body’s absorption of calcium.
From the perspective of environmental science and ecological engineering: due to its excellent biodegradability, it may be made into cheap, environmental protection packaging materials that can replace plastic bags with nano carbon particles, silicon particles, natural biomaterials, and other polymer materials in the future.
In the future, various collagen peptide products with rich biological functions will be extracted and prepared by different methods. As a result, they will be widely used in health products, cosmetics, bioengineering materials, medical equipment, and other fields. In short, collagen peptides will occupy an increasing share in the international and domestic market, play an essential role in people’s daily life, have a far-reaching impact on the people, create greater social and economic benefits, and have excellent development potential and market prospects.